The Domestication Syndrome

NPR's "Skunk Bear" program does a fine job of explaining the connection between neural crest cells, which, among other things, fuel the fight or flight response in mammals which is not advantageous to developing a strong relationship with humans, and the "domestication syndrome" which emerges when this cells are fewer or less well functioning, which are variety of phenotypic side effects of having fewer or less well functioning neural crest cells.