[M]ice lacking IAP have leaky guts, as well as excess endotoxin and inflammatory molecules in their blood. The knockout animals are also obese and have insulin resistance, a sign of diabetes.
The team then looked at the effects feeding mice IAP as a supplement to a high-fat diet. A daily dose of IAP (it’s a powder that dissolves in the animals’ drinking water) for 11 weeks prevented all of the problems that develop in mice eating the high-fat diet alone — insulin resistance, leaky gut, blood endotoxin, inflammation, and weight gain.
In yet another set of experiments, the researchers fed mice a high-fat diet and allowed them to fully develop metabolic syndrome and obesity. Then they gave them the IAP supplement for six weeks. In these animals, IAP reduced endotoxin levels, inflammation and glucose intolerance. If the fat mice had taken the supplement for a longer period of time, their condition may have reversed even more[.]Essentially, IAP supplements hold the promise of a diet pill that works not by curbing hunger, but by changing the way the body processes what it eats.