How do we deprogram the roughly 50 million American voters who are just flat out delusional and actively insulate themselves from more reliable sources of information? Will those who have been fooled by Trump's lies about election fraud in the 2020 Presidential election come to accept the fair and square results that we had (for the most part)?
Will authorities continue to follow through on the way of anti-domestic terrorism action that they took following the January 6 seditious riot at the Capitol? Will regulation of police abuses and the cause of racial justice that Biden championed in his inauguration speech actually improve?
Will we be able to unwind the national surge in murders that we experienced in 2020?
Will Trump be convicted of the impeachment charges he faces? Is the Republican Party actually at risk of a schism between Trumpists and more traditional conservatives? Has a large minority of the GOP lost the support of Big Business for the foreseeable future?
Can we smooth out the inevitable decline in the rural population of the U.S. that has left large swaths of the U.S. in a state of malaise?
How do we roll out a COVID-19 vaccine while keeping new more virulent strains which may not be as deterred by the vaccine under control? Will this allow schools from pre-K to college return to business as usual by the fall of 2021? Will women who have disproportionately left the labor force in droves in 2020 return to work when and if that happens? How do we treat and manage the months long serious symptoms of the many millions of Americans who have contracted COVID-19 but not died from it? What will be the long term demographic and societal consequences of the 2020 baby bust in a year when births had already been on track to reach record lows before COVID? Will the people who have been hardest hit economically by COVID-19 be able to recover when it's over?
How do we establish a battery charging infrastructure that in conjunction with new battery technology ready to be available in the mass new vehicle retail sales market in three to six years can bring us to a tipping point where electric vehicles dramatically increase their market share (currently 1.9% of new vehicles which replace 1/7th of the vehicles on the road each year or less)? What other Paris Climate Accord and Biden Administration climate change policies will we need.
Will Democrats in Washington D.C. be able to pass significant legislation despite a lack of a filibuster-proof majority and the will within its caucus to use the nuclear option to abolish the legislative filibuster? Will election law reforms and redistricting reforms be in place in time to have an effect in the 2022 election? Will efforts to provide a rapid path to citizenship for millions of foreign born people who reside permanently in the U.S. bear fruit quickly enough to impact the 2022 election outcomes?
Will the U.S. be able to mend ties with its historic allies whom it alienated during the Trump Administration? Will U.S. exporters be able to recapture foreign markets that it ceded to other exporters as a result of Trump's trade wars?
Will marijuana decriminalization at the federal level, and more generally, a deescalation of the "war on drugs" come to pass?